I did a quick forum search and was surprised this hasn't been mentioned yet.
BloodCM (CrossMatching) - http://www.moddb.com/games/bloodcm - is a total conversion but based on eDuke3D. Check the videos out. It looks so good and realistically close to the original gameplay. Note that this is a big step up from BloodTC which was a total conversion of Doom.
Blood - lives again!!!!
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